Collect. Czech. Chem. Commun.
1979, 44, 2573-2582
https://doi.org/10.1135/cccc19792573
Synthesis and properties of oxytocin analogues acting as irreversible inhibitors of the uterotonic response to oxytocin
Michal Lebl, Vera Bojanovska, Tomislav Barth and Karel Jošt
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
A series of compounds containing reactive groups of different chemical character was synthetized from [4-glutamic acid]deamino-1-carba-oxytocin or from [2-O-methyltyrosine, 4-glutamic acid]deamino-1-carba-oxytocin. The analogues acted as specific irreversible inhibitors of the uterotonic response to oxytocin. Active esters of the initial compounds were the most effective inhibitors.
