Collect. Czech. Chem. Commun.
1980, 45, 1132-1136
https://doi.org/10.1135/cccc19801132
Activation of adenylate cyclase from rat renal medulla by some oxytocin analogs
Věra Klenerováa, Miroslav Munclingera, Sixtus Hynieb, Tomislav Barthc and Karel Joštc
a Institute of Pathological Physiology, Faculty of General Medicine, Charles University, 128 00 Prague 2
b Institute of Pharmacology, Faculty of General Medicine, Charles University, 128 00 Prague 2
c Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
The ability of carba-analogs of oxytocin to activate adenylate cyclase was followed on the crude enzyme preparation from rat renal medulla. Their stimulating effects on adenylate cyclase activity were in a correlation with their antidiuretic potency. There is discussed the dependence of the affinity of carba-analogs of oxytocin to stimulate adenylate cyclase and their antidiuretic potency on the character of changes in the primary structure of these drugs.
