The effect of some structural modifications of the oxytocin molecule on the duration of the galactogogic response

Barth, Tomislav; Slaninová, Jiřina; Servítová, Linda; Lebl, Michal; Kotsira-Engonopoulos, Christine; Tzougraki, Chrysa; Photaki, Iphigenia; Krojidlo, Milan; Jošt, Karel

doi:10.1135/cccc19812441

CCCC > Archive > 1981, Volume 46 > Issue 10 > p. 2441

The effect of some structural modifications of the oxytocin molecule on the duration of the galactogogic response

Tomislav Barth^a, Jiřina Slaninová^a, Linda Servítová^a, Michal Lebl^a, Christine Kotsira-Engonopoulos^b, Chrysa Tzougraki^b, Iphigenia Photaki^b, Milan Krojidlo^a and Karel Jošt^a

^a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
^b Laboratory of Organic Chemistry, The university of Athens, Athens 144, Greece

Abstract

The duration of the galactogogic response to analogues of oxytocin, modified mainly in the aminoterminal part of the molecule, was determined in experiments with lactating rats. The influence of the individual structural modifications was investigated by determining the dependence of both the intensity of the effect and the total effect of the compound on the log dose.

Previous abstract Next abstract

Collection of Czechoslovak Chemical Communications - digital archive

The effect of some structural modifications of the oxytocin molecule on the duration of the galactogogic response

Abstract