Collect. Czech. Chem. Commun.
1981, 46, 1983-1989
https://doi.org/10.1135/cccc19811983
Use of phenylacetyl group for protection of the lysine Nε-amino group in synthesis of peptides
František Brtník, Tomislav Barth and Karel Jošt
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
Nε-Phenylacetyllysine was used in the synthesis of deamino-lysine-vasopressin. The phenylacetyl protecting group is stable under conditions of peptide synthesis and can be removed by action of penicillin amidohydrolase (E.C.3.5.1.11) without damaging the built peptide chain.
