Collect. Czech. Chem. Commun.
1982, 47, 2749-2762
https://doi.org/10.1135/cccc19822749
Synthesis of 4,4- and 5,5-disubstituted 4,5-dihydro-6H-canthin-6-ones
Josef Hájíček, Jiří Holubek and Jan Trojánek
Research Institute for Pharmacy and Biochemistry, 194 04 Prague 9
Abstract
The paper describes regiospecific synthesis of 4,4- and 5,5-disubstituted 4,5-dihydro-6H-canthin-6-ones III and XVIII, starting from half-esters of 2,3-disubstituted succinic acids, V and XIV. The formation of the anomalous 5,5-disubstituted canthin-4,6-diones XVII is ascribed to oxidation of the intermediate XIX. The 1H NMR spectra of the compounds prepared are discussed.
