Collect. Czech. Chem. Commun. 1982, 47, 1339-1345
https://doi.org/10.1135/cccc19821339

7-(3-Substituted amino-2-hydroxypropyl)-8-benzyl-, or -8-phenyltheophyllines

Ladislav Štibrányia, Alfonz Rybára, Ján Jendrichovskýa, Lýdia Boženkováa and Vladimír Kovalčíkb

a Research Institute for Drugs, 801 00 Bratislava
b Department of Pharmacology, Comenius University, 884 24 Bratislava

Abstract

N-Substituted derivatives of 7-(3-amino-2-hydroxypropyl)-8-benzyl- (V), or -8-phenyltheophylline (VI) were prepared by addition of the appropriate amines to 7-epoxypropyl-8-benzyl- (III), or -8-phenyltheophyllines (IV). Compounds III and IV were obtained by alkylation of 8-benzyl-, or 8-phenyltheophyllines with 1-chloro-2,3-epoxypropane. DerivativesV and VI exhibited a peripheral vasodilatation effect in vitro.