Collect. Czech. Chem. Commun.
1982, 47, 2145-2149
https://doi.org/10.1135/cccc19822145
Some 1-β-D-ribofuranosyl-5-phenylcytosines and -5-(2-chlorophenyl)-2-thiocytosine
Zdeněk Buděšínskýa, František Šmejkala and Miloš Buděšínskýb
a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
b Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
5-Phenylcytidine (XI), 5-(4-nitrophenyl)cytidine (XII) and 5-(2-chlorophenyl)-2-thiocytidine (XIII) were prepared from corresponding trimethylsilyl derivatives V-VII. Nitro derivative XII was converted to amino derivative XIV by catalytic reduction. Cytidines XI-XIV and the starting cytosines I-IV do not display any in vitro inhibitory effect against the influenza virus AWS, virus NDV, vaccinia, herpes simplex and WEE, or in vivo effect on mice infected with the herpes simplex virus type 2 (HSV-2) either.
