Collect. Czech. Chem. Commun.
1983, 48, 2088-2095
https://doi.org/10.1135/cccc19832088
Growth inhibition of Escherichia coli B by nucleoside analogs
Markyta Bártováa, Miloš Rybaa, Zdena Jedličkováb, Ladislav Novotnýa, Hubert Hřebabeckýa and Jiří Beráneka
a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Institute for Postgraduate Medical and Pharmaceutical Education, 100 05 Prague 10
Abstract
The inhibition of growth of Escherichia coli B by series of 6-azaanalogs of pyrimidine nucleosides, their precursors, and analogs of cancerostatic agents 5-fluorouracil and arabinosylcytosine is reported. A very high antibacterial activity is observed with most of the 5-fluorouracil nucleosides where a cleavage (30%) to 5-fluorouracil is observed at the most active compounds (5-fluorouridine, 5-fluoro-2'-deoxyuridine). Arabinosylcytosine and its derivatives express very low activity.
