Collect. Czech. Chem. Commun.
1986, 51, 1311-1315
https://doi.org/10.1135/cccc19861311
Synthesis of 2-amino-5-β-D-ribofuranosyl-1,3,4-thiadiazole and 2-amino-β-D-ribofuranosyl-1,3,4-oxadiazole
Hubert Hřebabecký
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
Benzoylated 2-amino-5-ribosylthiadiazole III and 2-amino-5-oxadiazole IV were synthesized by cyclization of allonoylthiosemicarbazide I and allonoylsemicarbazide II with phosphorus pentoxide in nitromethane. The oxadiazole IV was alternatively prepared by heating compound I with lead(II)oxide in acetonitrile. Free ribosylthiadiazole V and ribosyloxadiazole VI were obtained by methanolysis of III and IV.
