Collect. Czech. Chem. Commun.
1991, 56, 2406-2412
https://doi.org/10.1135/cccc19912406
Synthesis and antibacterial activity of new 7-substituted fluoroquinolones
Stanislav Rádl and Lenka Kovářová
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Reaction of substituted 3-carboxyquinolone derivatives IIIa, IIIb, IIIc, and IV with 4-pyridone ethylene ketal in pyridine afforded corresponding 7-substituted derivatives VIa, VIb, VIc, and VIIa, respectively. Acidic deprotection of these compounds yielded respective oxo derivatives VId,VIe, VIf, and VIIb which were converted to their oximes If, Ig, Ih, and IIb.
