Collect. Czech. Chem. Commun.
1992, 57, 1747-1757
https://doi.org/10.1135/cccc19921747
The Uses of Ethyl Cyanobromoacetate in Heterocyclic Synthesis: Novel Synthesis of Thiophene, Pyrazolo[3,4d]thiazole and Thieno[2,3d]pyridazine Derivatives
Rafat Milad Mohareba, Salah El-Kousyb and Abdel Monem El-Torgomanb
a Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
b Chemistry Department, Faculty of Science, Menofia University, Shibin El-Kom, Egypt
Abstract
The reaction of active methylene reagents Ia-Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa-IVe. The use of IVa-IVe in heterocyclic synthesis was described.
