Collection of Czechoslovak Chemical Communications - digital archive 

Abstract

Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr(SO₃^-Na⁺)-Met-Gly-Trp-Met-Asp-Phe-NH₂) Ia and its seven analogues Ib - Ih. In the analogues Ib and Ic the Met residue in the carboxyterminal part of the molecule was substituted for L- or D-Phe Me₃. In the analogues Id and Ie with Phe residue substituted by L- or D-Phe Me₃ the Neo was inserted in the place of this Met residue and in the analogues If and Ig, an addition to PheMe₃ substitution in the carboxyterminus, both Met residues were replaced for Neo. This dual substitution for Met residues was also applied in the analogue Ih with coded Phe residue in the C-terminus.