Dependence of log k Obtained by HPLC on log P'exp in the Series Piperidino and Morpholinoethyl Esters of o-, m- and p-Alkoxy Substituted Phenylcarbamic Acids

Sedlárová, Eva; Čižmárik, Jozef; Novosedlíková, Dana; Podhorová, Katarína; Šranková, Lucia; Šrank, Andrej

doi:10.1135/cccc19930310

CCCC > Archive > 1993, Volume 58 > Issue 2 > p. 310

Dependence of log k Obtained by HPLC on log P'_exp in the Series Piperidino and Morpholinoethyl Esters of o-, m- and p-Alkoxy Substituted Phenylcarbamic Acids

Eva Sedlárová^a, Jozef Čižmárik^a, Dana Novosedlíková^a, Katarína Podhorová^a, Lucia Šranková^b and Andrej Šrank^b

^a Department of Pharmaceutical Chemistry, Comenius University, 832 32 Bratislava, Slovak Republic
^b Slovakofarma, 920 27 Hlohovec, Slovak Republic

Abstract

Dependence of log k obtained by the HPLC method on log P'_exp obtained by the classical method was investigated in two series of basic ethyl phenylcarbamic acids. The linear dependence was found with o-substituted series and p-substituted morpholino derivatives. The relation with p-derivatives of the piperidino series is close to linearity, while that of m-derivatives of both series is not linear.

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Dependence of log k Obtained by HPLC on log P'exp in the Series Piperidino and Morpholinoethyl Esters of o-, m- and p-Alkoxy Substituted Phenylcarbamic Acids

Abstract

Dependence of log k Obtained by HPLC on log P'_exp in the Series Piperidino and Morpholinoethyl Esters of o-, m- and p-Alkoxy Substituted Phenylcarbamic Acids