Collect. Czech. Chem. Commun.
1993, 58, 693-701
https://doi.org/10.1135/cccc19930693
Biologically Important Physicochemical Properties of Kojic Acid Derivatives
Štefan Baláža, Ernest Šturdíka, Regina Ujhelyováa, Dušan Valigurab, Michal Uherc, Miroslav Veverkab, Václav Konečnýd, Jana Adamcováa, Peter Michalíke and Július Brtkof
a Department of Biochemical Technology, Slovak Technical University, 812 27 Bratislava, Slovak Republic
b Department of Inorganic Chemistry, Slovak Technical University, 812 27 Bratislava, Slovak Republic
c Department of Organic Chemistry, Slovak Technical University, 812 27 Bratislava, Slovak Republic
d Research Institute of Chemical Technology, 831 06 Bratislava, Slovak Republic
e Research Institute of Starch Industry, 820 06 Bratislava, Slovak Republic
f Institute of Endocrinology, Slovak Academy of Sciences, 833 06 Bratislava, Slovak Republic
Abstract
Physicochemical properties (hydrophobicity, acidity, metal complexing ability), which are expected to play a role in biological activity of kojic acid derivatives, were determined for 35 compounds. The structure-property relationship were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correlation factors according to Leo and Hansch as well as between acidity and a set of Hammett constants of the varying substituents.
