Collect. Czech. Chem. Commun.
1993, 58, 1363-1370
https://doi.org/10.1135/cccc19931363
Copper(II) Dihydroxybenzoates; Synthesis and Properties
Jozef Sokolíka, Brigita Lučanskáa, Gustáv Pleschb, Ingrid Tumovác, Aladár Valenta, Pavel Švecc and Juraj Krätsmár-Šmogroviča
a Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovak Republic
b Institute of Inorganic Chemistry, Slovak Academy of Sciences, 842 36 Bratislava, Slovak Republic
c Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovak Republic
Abstract
Compounds of composition Cu(2,5-DHB)2 . 4 H2O (DHB, dihydroxybenoate anion) and Cu(2,Y-DHB)2 . 8 H2O (Y = 4 or 6) were prepared as potential antiinflamatory gents with a view of pharmacological screening. The room-temperature magnetic moments allow to classify all compounds into the group of magnetically diluted copper(II) complexes. According the EPR and electronic spectra, the degree of tetragonal distortion increases passing from Cu(2,6-DHB)2 . 8 H2O (III) through Cu(2,4-DHB)2 . 8 H2O (I) to Cu(2,5-DHB)2 . 4 H2O (II. The complexes differ also in the cooperative ordering in their structures. All tested compounds exhibit higher antiinflamatory activities (on dextran edema) than free carboxylic acids. However, their effects were accompanied with relatively high toxicity. Remarkable results were also achieved on evaluating the antipyretic activity.
