Collect. Czech. Chem. Commun.
1994, 59, 2127-2165
https://doi.org/10.1135/cccc19942127
Prodrugs of Analogs of Nucleic Acid Components
Petr Alexander and Antonín Holý
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
Abstract
This review regards various attitudes to the rational design of prodrugs derived of nucleoside and nucleotide analogues with pronounced biological (antiviral, anticancer) activity. Particular attention is focused on the recent development of prodrugs of approved therapeutic agents with the above structural association.
