Collect. Czech. Chem. Commun. 1994, 59, 2533-2544
https://doi.org/10.1135/cccc19942533

Synthetic Analogues of 15,15-Acetals of Prostaglandin F2α and E2

Václav Kozmík and Jaroslav Paleček

Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic

Abstract

Two series of 15,15-ethyleneacetals of PG F2α and PG E2 modified both in the α- and ω-chains were prepared with a view to find more stable and efficient analogues of this type. The synthesis of the analogues starting from the easily available (±)-[(3aα,4α,5β,6aα)]-5-(1,1'-biphenylyl-4-carbonyloxy)-4-formylhexahydro-2H-cyclopenta[b]furan-2-one, the so-called Corey aldehyde I, was based on conventional procedures, some of which were modified to achieve the optimum yields.