Collect. Czech. Chem. Commun.
1994, 59, 1892-1896
https://doi.org/10.1135/cccc19941892
Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles and Their Precursors
Eva Jedlovská and Edita Gavláková
Department of Organic Chemistry, Slovak Technical University, 812 37 Bratislava, Slovak Republic
Abstract
The characteristic feature of many commercial agrochemicals and drugs is the 5-nitro-2-furyl or 2,5-dimethyl-3-furyl building block. Within the scope of our research aimed at utilization of dipolar cycloaddition reactions to prepare new compounds with potential biological and phytoeffectorial activity, we report on the synthesis of some substituted hydrazones I and their intramolecular cycloaddition to 2,5-disubstituted 1,3,4-oxadiazoles II. The basic IR, 1H NMR as well as mass spectral data of final products are presented.
