Collect. Czech. Chem. Commun. 1995, 60, 115-126
https://doi.org/10.1135/cccc19950115

Sterically Crowded Heterocycles. II. Conformational Structure of 2-Phenyl-3-[(Z)-1,3-diphenyl-3-oxopropenyl]imidazo[1,2-a]pyridine and Related Compounds

Stanislav Böhma, Richard Kubíka, Martin Hradilekb, Jan Němečekc, Michal Hušákd, Bohumil Kratochvíld and Josef Kuthana

a Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
c Institute of Microbiology, Academy of Sciences of the Czech Republic, 141 20 Prague 4, Czech Republic
d Institute of Solid State Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic

This article is part of serial Sterically crowded heterocycles.

Abstract

Conformational behaviour of 2-phenyl-3-[(Z)-1,3-diphenyl-3-oxopropenyl]imidazo[1,2- a]pyridine I is studied using a molecular isoenergy map calculated by the PM3 method. A predicted potency of this approach is discussed with respect to the experimental solid state structures of related compounds I - IV. Complete X-ray structures of 7-methyl derivative IV and 11-phenyl derivative V are reported.