Collect. Czech. Chem. Commun. 1996, 61, 1380-1385
https://doi.org/10.1135/cccc19961380

Sterically Crowded Heterocycles. VI. Relative Configuration of Diastereoisomeric (Z)-1,3-Diphenyl-3-(5-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-en-1-ols

Jan Čejkaa, Richard Kubíkb, Bohumil Kratochvíla and Josef Kuthanb

a Department of Solid State Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic

This article is part of serial Sterically crowded heterocycles.

Abstract

Relative configuration of the titled racemic compounds 1a and 1b has been elucidated on the basis of a complete X-ray structure determined for the higher melting diastereoisomer. The compound 1a crystallizes in the orthorhombic space group P21212, a = 15.610(3) Å, b = 18.634(4) Å, c = 7.5672(7) Å, V = 2201.1(6) Å3, Z = 4. Preparative separation of both diastereoisomers is reported.

Keywords: X-Ray analysis; Diastereoisomerism; Imidazo[1,2-a]pyridines.