Collect. Czech. Chem. Commun.
1997, 62, 42-46
https://doi.org/10.1135/cccc19970042
Titration of Mercaptans and Some Mercaptan-Based Drugs with Iodine Monobromide in Non-Aqueous Dimethyl Sulfoxide
D. K. Sharma, B. S. Sambra, N. Verma and B. C. Verma
Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, 171005 India
Abstract
Mercaptans undergo smooth and quantitative oxidation to the corresponding disulfides with iodine monobromide in non-aqueous (dimethyl sulfoxide) medium, which has been made the basis of a simple, rapid and rugged method for the determination of mercaptan-based drugs viz. mercaptopurine and dimercaprol. The method has been thoroughly tested with a number of mercaptans before applying it to drugs. The salient features of the method are discussed.
Keywords: Titration; Mercaptans; Iodine monobromide; Dimethyl sulfoxide.
