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Collect. Czech. Chem. Commun. 1997, 62, 498-509
https://doi.org/10.1135/cccc19970498

Chiral Forms of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid (Flobufen) and Its Metabolite.Synthesis and Basic Biological Properties

Miroslav Kuchařa, Marie Poppováa, Antonín Janderaa, Vladimíra Panajotovováa, Hana Zůnováa, Miloš Buděšínskýb, Hana Tomkováa, Alexandr Jegorovc and Jan Taimra

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic
b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic,166 10 Prague 6, Czech Republic
c Galena, a.s., 370 05 České Budějovice, Czech Republic

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  • Liu Xian, Wen Jialin, Yao Lin, Nie Huifang, Jiang Ru, Chen Weiping, Zhang Xumu: Highly Chemo- and Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids. Org. Lett. 2020, 22, 4812. <https://doi.org/10.1021/acs.orglett.0c01618>
  • Hessler Filip, Korotvička Aleš, Nečas David, Valterová Irena, Kotora Martin: Syntheses of a Flobufen Metabolite and Dapoxetine Based on Enantioselective Allylation of Aromatic Aldehydes. Eur J Org Chem 2014, 2014, 2543. <https://doi.org/10.1002/ejoc.201301899>
  • Guo Meng-Ping, Deng Ji-Hua, Zhang Qiao-Chu, Guo Hui-Rui, Yuan Lin: 1-(2′,4′-Difluorobiphenyl-4-yl)ethanone. Acta Crystallogr E Struct Rep Online 2008, 64, o1923. <https://doi.org/10.1107/S1600536808028596>
  • Kuchař Miroslav, Kmoníček Vojtěch, Panajotová Vladimíra, Jandera Antonín, Brunová Bohumila, Junek Richard, Bucharová Věra, Čejka Jan, Šatinský Dalibor: Derivatives of (Phenylsulfanyl)benzoic Acids with Multiple Antileukotrienic Activity. Collect. Czech. Chem. Commun. 2004, 69, 2098. <https://doi.org/10.1135/cccc20042098>
  • Abouzid Khaled A. M., El-Abhar H. S.: Synthesis and antiinflammatory activity of novel indazolones. Arch Pharm Res 2003, 26, 1. <https://doi.org/10.1007/BF03179922>
  • KUCHAR M., POPPOVA M., JANDERA A., PANAJOTOVOVA V., ZUNOVA H., BUDESINSKY M., TOMKOVA H., JEGOROV A., TAIMR J.: ChemInform Abstract: Chiral Forms of 4‐(2′,4′‐Difluorobiphenyl‐4‐yl)‐2‐methyl‐4‐oxobutanoic Acid (Flobufen) and Its Metabolite. Synthesis and Basic Biological Properties. ChemInform 1997, 28. <https://doi.org/10.1002/chin.199731226>