Collect. Czech. Chem. Commun.
1997, 62, 1325-1341
https://doi.org/10.1135/cccc19971325
Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1
Miroslav Terinek, Václav Kozmík and Jaroslav Paleček
Institute of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6,Czech Republic
Abstract
Four optically pure isomers of methyl 11,16-dihydroxy-16-methyl-9-oxoprost-13-enoate (1a-1d) were synthesized using an approach reverse to the classical Corey procedure, the key intermediates being the easily accessible (-)- and (+)-enantiomers of the Corey lactone, 2a and 2b.
Keywords: Prostaglandins; Enantiomeric resolution.
