Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera <i>Hyrtios erecta</i>

Pettit, George R.; Cichacz, Zbigniew A.; Tan, Rui; Herald, Delbert L.; Melody, Noeleen; Hoard, Michael S.; Doubek, Dennis L.; Hooper, John N. A.

doi:10.1135/cccc19981671

CCCC > Archive > 1998, Volume 63 > Issue 10 > p. 1671

Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta

George R. Pettit^a, Zbigniew A. Cichacz^a, Rui Tan^a, Delbert L. Herald^a, Noeleen Melody^a, Michael S. Hoard^a, Dennis L. Doubek^a and John N. A. Hooper^b

^a Cancer Research Institute and Department of Chemistry, Arizona State University, Tempe, Arizona 85287-2404, U.S.A.
^b Queensland Museum, P.O. Box 3300 S. Brisbane, Queensland 4101, Australia

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3·10^-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED₅₀ 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Keywords: Natural products; Terpenes; Sesterterpenes; Scalorolides; Marine sponge; NMR spectroscopy; X-Ray diffraction; Crystal structure.

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Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta

Abstract