Collect. Czech. Chem. Commun.
1998, 63, 2085-2091
https://doi.org/10.1135/cccc19982085
Immunostimulant Activity of Peptides Related to Human β-Casein Fragment Gly-Leu-Phe
Sushma Shuklaa, Anju Purib, Ragini Sahaib, Bijoy Kundua, Lalit M. Tripathib and Vishwa M. L. Srivastavab
a Division of Biopolymers, Central Drug Research Institute, Lucknow 226001, India
b Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India
Abstract
Twenty novel analogues of β-casein fragment (Gly-Leu-Phe) have been synthesised and evaluated in mouse for their impact on macrophage migration and humoral response to sheep red blood cells. As an outcome of the present investigation, compound 1 has been found to be very promising.
Keywords: Peptides; Tripeptides; Macrophage activation; Humoral response; Sheep red blood cells; Immunomodulators.
