Collect. Czech. Chem. Commun.
2000, 65, 1145-1155
https://doi.org/10.1135/cccc20001145
Glycosylation of 1-Aminoimidazole-2(3H)-thiones
Irene M. Lagoja, Arthur Van Aerschot, Chris Hendrix and Piet Herdewijn*
Laboratory of Medicinal Chemistry, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium
Abstract
The selectivity of the glycosylation of 1-aminoimidazole-2(3H)-thiones can be controlled. Depending on the chosen conditions, either the kinetically favored S-glycosides or the thermodynamically more stable N-glycosylated compounds are obtained in only one anomeric configuration (β-anomer).
Keywords: 1-Aminoimidazole-2(3H)-thiones; Nucleosides; Glycosylations; Glycosidations; Ribosides; Imidazoles.
References: 24 live references.
