Collect. Czech. Chem. Commun.
2002, 67, 47-54
https://doi.org/10.1135/cccc20020047
Synthesis of cis and trans Isomers of D-Ring Linked Bis-Steroid Pyrazines from 16α-Bromo-17-oxosteroids
Zenon Łotowski*, Jacek W. Morzycki, Izabella S. Niewczas and Marta Zdanowicz
Institute of Chemistry, University of Bialystok, al. Pilsudskiego 11/4, 15-443 Bialystok, Poland
Abstract
Treatment of 16α-bromo-17-oxosteroids 1 and 2 with gaseous ammonia and successive air-oxidation afforded the cis and trans isomers of D-linked bis-steroid pyrazines. Analogous reaction of 1α-bromo-4-nor-5α-cholestan-2-one (3) led to unexpected hydrolysis products.
Keywords: Steroids; Bis-steroidal pyrazines; α-Bromo ketones; Enamines; Cephalostatin analogs.
References: 18 live references.
