Collect. Czech. Chem. Commun.
2003, 68, 744-750
https://doi.org/10.1135/cccc20030744
A Facile Synthesis of Selectively Protected Linear Oligoamines
Simona Koščová, Miloš Buděšínský and Jana Hodačová*
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic
Abstract
A convenient multi-gram preparative method for the synthesis of linear oligoamines having the terminal primary amino groups unprotected and the central secondary amino functions protected with tert-butoxycarbonyl groups is presented. At the same time, simple one-pot preparation of the α,ω-bis(trifluoroacetamide) intermediates 2 has been developed. NMR spectra of the novel selectively protected oligoamines are also discussed.
Keywords: Amines; NMR spectroscopy; Protecting groups; Azacrown macrocycles; Polyamines; Building blocks.
References: 14 live references.
