Collect. Czech. Chem. Commun.
2005, 70, 339-349
https://doi.org/10.1135/cccc20050339
Novel Method for Preparation of Highly Substituted 6-Arylpurines by Reactions of 6-Alkynylpurines with Zirconacyclopentadienes
Pavel Tureka,b, Martin Kotoraa,b,*, Michal Hoceka,* and Ivan Votrubaa
a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic
b Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague 2, Czech Republic
Abstract
Reactions of various zirconacyclopentadienes bearing alkyl and aryl groups with 6-alkynylpurines in the presence of NiBr2(PPh3)2 afforded the corresponding 6-arylpurines with highly hydrophobic aryl moieties in low to moderate yields. Some of the title purines showed interesting cytostatic activity.
Keywords: Purines; Nucleosides; Alkynes; Cyclotrimerizations; Zirconium; Nickel; Cytostatic activity.
References: 36 live references.
