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Collect. Czech. Chem. Commun. 2005, 70, 1465-1481
https://doi.org/10.1135/cccc20051465

Simple Transformation of Thymine 1-[3-Hydroxy-2-(phosphonomethoxy)propyl] Derivatives to Their 1-[3-Fluoro-2-(phosphonomethoxy)propyl] Counterparts

Karel Pomeisl*, Radek Pohl, Antonín Holý and Ivan Votruba

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-166 10, Prague 6, Czech Republic

Crossref Cited-by Linking

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  • Krečmerová Marcela, Majer Pavel, Rais Rana, Slusher Barbara S.: Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects. Front. Chem. 2022, 10. <https://doi.org/10.3389/fchem.2022.889737>
  • Dorababu Atukuri: Evolution of uracil based thymidine phosphorylase inhibitors, SAR and electronic correlation: revisit. Drug Development Research 2019, 80, 893. <https://doi.org/10.1002/ddr.21592>
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  • Luo Min, Groaz Elisabetta, Andrei Graciela, Snoeck Robert, Kalkeri Raj, Ptak Roger G., Hartman Tracy, Buckheit Robert W., Schols Dominique, De Jonghe Steven, Herdewijn Piet: Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs. J. Med. Chem. 2017, 60, 6220. <https://doi.org/10.1021/acs.jmedchem.7b00416>
  • Pomeisl Karel, Beier Petr, Pohl Radek, Krečmerová Marcela: Novel and Efficient Synthesis of gem‐Difluorinated Derivatives of Acyclic Nucleoside Phosphonates (ANPs). ChemistrySelect 2016, 1, 2102. <https://doi.org/10.1002/slct.201600445>
  • Baszczyňski Ondřej, Janeba Zlatko: Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates. Medicinal Research Reviews 2013, 33, 1304. <https://doi.org/10.1002/med.21296>
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  • Birck Matthew R., Clinch Keith, Gainsford Graeme J., Schramm Vern L., Tyler Peter C.: Syntheses of 5‐Chlorouracils/Thymines with 1‐[Phosphono(Methyl/Difluoromethyl)]‐1,2‐Unsaturated‐Moiety‐Substituted Methyl Groups at N(1) and Human Thymidine Phosphorylase Inhibitory Activity. Helvetica Chimica Acta 2009, 92, 823. <https://doi.org/10.1002/hlca.200900003>
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  • Pomeisl Karel, Pohl Radek, Holy Antonin, Votruba Ivan: Simple Transformation of Thymine 1‐[3‐Hydroxy‐2‐(phosphonomethoxy)propyl] Derivatives to Their 1‐[3‐Fluoro‐2‐(phosphonomethoxy)propyl] Counterparts. ChemInform 2006, 37. <https://doi.org/10.1002/chin.200612221>
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