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Collect. Czech. Chem. Commun. 2006, 71, 1169-1185
https://doi.org/10.1135/cccc20061169

The Effect of pH on Peroxidase-Mediated Oxidation of and DNA Adduct Formation by Ellipticine

Jitka Poljakováa, Martin Dračínskýa, Eva Freib, Jiří Hudečeka and Marie Stiborováa,*

a Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
b Division of Molecular Toxicology, German Cancer Research Center, In Neuenheimer Feld 280, 69120 Heidelberg, Germany

Crossref Cited-by Linking

  • Stiborová Marie, Černá Věra, Moserová Michaela, Mrízová Iveta, Arlt Volker, Frei Eva: The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes. IJMS 2014, 16, 284. <https://doi.org/10.3390/ijms16010284>
  • Masood Farha, Chen P., Yasin Tariq, Hasan Fariha, Ahmad Bashir, Hameed Abdul: Synthesis of poly-(3-hydroxybutyrate-co-12 mol % 3-hydroxyvalerate) by Bacillus cereus FB11: its characterization and application as a drug carrier. J Mater Sci: Mater Med 2013, 24, 1927. <https://doi.org/10.1007/s10856-013-4946-x>
  • Poljaková Jitka, Eckschlager Tomáš, Činátl Jindřich, Kizek René, Frei Eva, Stiborová Marie: Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these Cells. International Journal of Electrochemical Science 2013, 8, 1573. <https://doi.org/10.1016/S1452-3981(23)14248-9>
  • Kizek Rene, Adam Vojtech, Hrabeta Jan, Eckschlager Tomas, Smutny Svatopluk, Burda Jaroslav V., Frei Eva, Stiborova Marie: Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances. J Pharmacol Ther 2012, 133, 26. <https://doi.org/10.1016/j.pharmthera.2011.07.006>
  • Stiborová M., Rupertová M., Frei E.: Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2011, 1814, 175. <https://doi.org/10.1016/j.bbapap.2010.05.016>
  • Stiborová Marie, Poljaková Jitka, Martínková Eva, Bořek-Dohalská Lucie, Eckschlager Tomáš, Kizek Rene, Frei Eva: Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdisciplinary Toxicology 2011, 4, 98. <https://doi.org/10.2478/v10102-011-0017-7>
  • Poljaková Jitka, Eckschlager Tomáš, Hraběta Jan, Hřebačková Jana, Smutný Svatopluk, Frei Eva, Martínek Václav, Kizek René, Stiborová Marie: The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells. Biochemical Pharmacology 2009, 77, 1466. <https://doi.org/10.1016/j.bcp.2009.01.021>
  • Stiborová Marie, Arlt Volker M., Henderson Colin J., Wolf C. Roland, Kotrbová Věra, Moserová Michaela, Hudeček Jiří, Phillips David H., Frei Eva: Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse. Toxicology and Applied Pharmacology 2008, 226, 318. <https://doi.org/10.1016/j.taap.2007.09.017>
  • Aimová Dagmar, Poljaková Jitka, Kotrbová Věra, Moserová Michaela, Frei Eva, Arlt Volker, Stiborová Marie: Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2. Interdisciplinary Toxicology 2008, 1, 160. <https://doi.org/10.2478/v10102-010-0033-z>
  • Poljaková Jitka, Frei Eva, Gomez Jacobo E., Aimová Dagmar, Eckschlager Tomáš, Hraběta Jan, Stiborová Marie: DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells. Cancer Letters 2007, 252, 270. <https://doi.org/10.1016/j.canlet.2006.12.037>
  • Dračínský Martin, Sejbal Jan, Rygerová Barbora, Stiborová Marie: An efficient modification of ellipticine synthesis and preparation of 13-hydroxyellipticine. Tetrahetron Lett 2007, 48, 6893. <https://doi.org/10.1016/j.tetlet.2007.07.160>
  • Stiborová Marie, Rupertová Martina, Aimová Dagmar, Ryšlavá Helena, Frei Eva: Formation and persistence of DNA adducts of anticancer drug ellipticine in rats. Toxicology 2007, 236, 50. <https://doi.org/10.1016/j.tox.2007.03.026>
  • Stiborová Marie, Dračínská Helena, Aimová Dagmar, Hodek Petr, Hudeček Jiří, Ryšlavá Helena, Schmeiser Heinz H., Frei Eva: The Anticancer Drug Ellipticine is an Inducer of Rat NAD(P)H:Quinone Oxidoreductase. Collect. Czech. Chem. Commun. 2007, 72, 1350. <https://doi.org/10.1135/cccc20071350>