CCCC 2008, Volume 73, Issue 2, Abstracts pp. 275-291, Buy article full text | Collection of Czechoslovak Chemical Communications

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Collect. Czech. Chem. Commun. 2008, 73, 275-291
https://doi.org/10.1135/cccc20080275

Human N⁶-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N⁶-Substituted Purine Acyclic Nucleoside Phosphonates

Markéta Schinkmanová^a,*, Ivan Votruba^a, Riri Shibata^b, Bin Han^b, Xiaohong Liu^b, Tomas Cihlar^b and Antonín Holý^a

^a Gilead Sciences Research Center, Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
^b Gilead Sciences, Foster City, CA 94404, U.S.A.

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Human N6-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N6-Substituted Purine Acyclic Nucleoside Phosphonates

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Human N⁶-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N⁶-Substituted Purine Acyclic Nucleoside Phosphonates