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Collect. Czech. Chem. Commun. 2010, 75, 1229-1247
https://doi.org/10.1135/cccc2010077
Published online 2010-11-18 07:31:56

Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans

Karel Naimana, Petr Hodeka, Jiří Liberdaa, Heinz H. Schmeiserb, Eva Freic and Marie Stiborováa,*

a Department of Biochemistry, Faculty of Natural Sciences, Charles University in Prague, Albertov 2030, 128 43 Prague 2, Czech Republic
b Research Group Genetic Alteration in Carcinogenesis, National Center for Tumour Diseases, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
c Division of Preventive Oncology, National Center for Tumour Diseases, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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  • Hao Zhenming, Hu Liming, Yan Ruyu, Pei Luyu, Mo Shanyan: Sensitive fluorescent detection of o-aminophenol by hemicyanine boronic acid. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2024, 304, 123341. <https://doi.org/10.1016/j.saa.2023.123341>
  • Naiman Karel, Dračínský Martin, Hodek Petr, Martínková Markéta, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant o-Anisidine in Rats. Toxicological Sciences 2012, 127, 348. <https://doi.org/10.1093/toxsci/kfs104>
  • Naiman Karel, Martínková Markéta, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2011, 726, 160. <https://doi.org/10.1016/j.mrgentox.2011.09.010>