Collect. Czech. Chem. Commun.
2011, 76, 1567-1577
https://doi.org/10.1135/cccc2011101
Published online 2011-12-23 08:51:26
Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines
Martin Dračínský*, Petr Jansa* and Tomáš Elbert
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic
Abstract
The hydrogen-to-deuterium isotope exchange reaction of hydrogen in position 5 of pyrimidine derivatives was studied using NMR techniques. The dependence of the reaction rate on the pH and on the solvent composition was explored. In tracer experiments using tritiated water, the application of this exchange reaction was tested for the preparation of pyrimidine derivatives labeled by tritium.
Keywords: Isotopic labeling; NMR spectroscopy; Nucleobases; Pyrimidines.
References: 31 live references.
