Collection Symposium Series 2014, 14, 375-376
https://doi.org/10.1135/css201414375
Published online 2015-07-06 23:08:54

Acyclic nucleoside bis-phosphonates as potent inhibitors of 6-oxopurine phosphoribosyltransferases

Petr Špaček, Dianne T. Keough, Silvie Vrbková, Lenka Slavětínská, Zlatko Janeba, Lieve Naesens, Michael D. Edstein, Marina Chavchich, Tzu-Hsuan Wang, John de Jersey, Luke W. Guddat and Dana Hocková

Individual author index pages


Other CCCC articles of these authors

  • Zlatko Janeba and Antonín Holý
    Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. Alkylation of 8-substituted adenines
    Symposium Series 1999, Vol. 2, pp. 260–262 [Abstract]
    Published online 2016-05-08 23:32:05
  • Dana Hocková, Milena Masojídková and Antonín Holý
    Significant influence of (N,N-dimethylamino)methylene protection at N6-position of adenine on regioselectivity of alkylations: Selective synthesis of 7-substituted adenines
    Symposium Series 1999, Vol. 2, pp. 257–259 [Abstract]
    Published online 2016-05-08 23:31:57
  • Dana Hocková, Antonín Holý and Milena Masojídková
    Synthesis of acyclic nucleotide analogues derived from 5-substituted 2,4-diamino-6-hydroxypyrimidines
    Symposium Series 2002, Vol. 5, pp. 326–327 [Abstract]
    Published online 2016-01-25 20:42:30
  • Michal Hocek and Dana Hocková
    Regioselective cross-coupling reactions in the synthesis of multisubstituted purine bases and nucleosides
    Symposium Series 2005, Vol. 7, pp. 213–216 [Abstract]
    Published online 2015-11-08 11:52:35
  • Zlatko Janeba, Antonín Holý and Zdeněk Zídek
    Biological properties of the C-8 substituted analogues of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
    Symposium Series 2011, Vol. 12, pp. 344–346 [Abstract]
  • Petr Jansa, Petr Špaček, Antonín Holý, Ivan Votruba and Zlatko Janeba
    Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol
    Symposium Series 2011, Vol. 12, pp. 467–468 [Abstract]
    Published online 2015-08-20 10:24:43
  • Marcela Krečmerová, Antonín Holý, Dana Hocková, Martin Dračínský, Dianne T. Keough and Luke W. Guddat
    9-[2-Hydroxy-3-(phosphonomethoxy)propyl] ("iso-HPMP") derivatives of purine bases and their side-chain modified analogues: synthesis and antimalarial activity
    Symposium Series 2011, Vol. 12, pp. 381–382 [Abstract]
    Published online 2015-08-20 10:19:45
  • Petr Jansa, Viktor Kolman and Zlatko Janeba
    Synthesis and biological properties of the 2'-trifluoro-methyl analogues of tenofovir
    Symposium Series 2011, Vol. 12, pp. 370–371 [Abstract]
    Published online 2015-08-20 10:19:23
  • Petr Jansa, Antonín Holý, Martin Dračínský, Ondřej Baszczyňski, Michal Česnek and Zlatko Janeba
    The unique impact of microwave irradiaton on the chemistry of acyclic nucleoside phosphonates
    Symposium Series 2011, Vol. 12, pp. 347–348 [Abstract]
    Published online 2015-08-20 10:18:28
  • Petr Jansa, Martin Maxmilian Kaiser, Antonín Holý and Zlatko Janeba
    A novel, highly stereoselective synthetic approach for the preparation of substituted 2,5-dihydro-2,5-dihydroxyfurans
    Symposium Series 2011, Vol. 12, pp. 339–341 [Abstract]
    Published online 2015-08-20 10:13:05
  • Lucie Čechová, Petr Jansa, Michal Šála, Martin Dračínský, Antonín Holý and Zlatko Janeba
    The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination of purines and pyrimidines
    Symposium Series 2011, Vol. 12, pp. 312–313 [Abstract]
    Published online 2015-08-20 10:12:06
  • Michal Česnek, Petra Břehová, Martin Dračínský, Antonín Holý and Zlatko Janeba
    The efficient synthesis of 2-aryl substituted pyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling
    Symposium Series 2011, Vol. 12, pp. 310–311 [Abstract]
    Published online 2015-08-20 10:12:01
  • Ondřej Baszczyňski, Petr Jansa, Dana Hocková, Zlatko Janeba, Martin Dračínský, Antonín Holý, Dianne T. Keough, John de Jersey and Luke W. Guddat
    3-Fluoro-2-(phosphonomethoxy)propyl hypoxanthine and guanine derivatives as inhibitors of plasmodial hypoxanthine-guanine-xanthine phosphoribosyltransferases
    Symposium Series 2011, Vol. 12, pp. 302–303 [Abstract]
    Published online 2015-08-20 10:11:43
  • Dana Hocková, Antonín Holý, Michal Česnek, Ondřej Baszczyňski, Tomáš Tichý, Marcela Krečmerová, Zlatko Janeba, Tina S. Skinner-Adams, Lieve Naesens, Dianne T. Keoughd, John de Jersey and Luke W. Guddat
    Acyclic nucleoside phosphonates as inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase: new anti-malarial chemotherapy leads
    Symposium Series 2011, Vol. 12, pp. 171–174 [Abstract]
    Published online 2015-08-20 10:00:19
  • Martin Maxmilian Kaiser, Pavel Novák, Šárka Rosenbergová, Lenka Poštová-Slavětínská, Ivan Rosenberg and Zlatko Janeba
    Oligonucleotides modified with acyclic nucleoside phosphonate (HPEP) units
    Symposium Series 2014, Vol. 14, pp. 293–294 [Abstract]
    Published online 2015-07-06 23:05:30
  • Zlatko Janeba, Lucie Čechová, Jiří Žurek, Eliška Procházková and Martin Dračínský
    Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines
    Symposium Series 2014, Vol. 14, pp. 285–286 [Abstract]
    Published online 2015-07-06 23:05:07
  • Eliška Procházková, Lucie Čechová, Jiří Žurek, Zlatko Janeba and Martin Dračínský
    Switchable intramolecular hydrogen bond in polysubstituted 5-nitrosopyrimidines
    Symposium Series 2014, Vol. 14, pp. 251–254 [Abstract]
    Published online 2015-07-06 23:03:40
  • Dana Hocková, Dianne T. Keough, Petr Špaček, Zlatko Janeba, Michael D. Edstein, Marina Chavchich, Tzu-Hsuan Wang, Wai Soon Eng, Nicholas P. West, John de Jersey and Luke W. Guddat
    Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases: potential antimalarial and antibacterial agents
    Symposium Series 2014, Vol. 14, pp. 107–110 [Abstract]
    Published online 2015-07-06 22:58:24
  • Petr Jansa*, Viktor Kolman, Alexandra Kostinová, Martin Dračínský, Helena Mertlíková-Kaiserová and Zlatko Janeba
    Efficient synthesis and biological properties of the 2′-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates
    2011, Vol. 76, Issue 10, pp. 1187–1198 [Abstract]
  • Petr Jansa*, Petr Špaček, Ivan Votruba, Petra Břehová, Martin Dračínský, Blanka Klepetářová and Zlatko Janeba
    Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the “click” protocol
    2011, Vol. 76, Issue 9, pp. 1121–1131 [Abstract]
  • Zlatko Janeba*, Milena Masojídková and Antonín Holý
    Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base
    2010, Vol. 75, Issue 3, pp. 371–381 [Abstract]
  • Silvie Vrbková*, Martin Dračínský and Antonín Holý
    Bifunctional Acyclic Nucleoside Phosphonates: 2. Symmetrical 2-{[Bis(phosphono)methoxy]methyl}ethyl Derivatives of Purines and Pyrimidines
    2007, Vol. 72, Issue 7, pp. 965–983 [Abstract]
  • Dana Hocková*, Milena Masojídková and Antonín Holý
    Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines
    2005, Vol. 70, Issue 2, pp. 247–258 [Abstract]
  • Michal Hocek*, Dana Hocková and Jan Štambaský
    Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides
    2003, Vol. 68, Issue 5, pp. 837–848 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives
    2001, Vol. 66, Issue 9, pp. 1393–1406 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of 8-Amino- and N-Substituted 8-Aminoadenine Derivatives of Acyclic Nucleoside and Nucleotide Analogs
    2001, Vol. 66, Issue 3, pp. 517–532 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purine-8(9H)-thione and 8-(Methylsulfanyl)adenine
    2000, Vol. 65, Issue 11, pp. 1698–1712 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purin-8(9H)-one
    2000, Vol. 65, Issue 7, pp. 1126–1144 [Abstract]
  • Dana Hocková*, Milena Masojídková and Antonín Holý
    7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine
    1999, Vol. 64, Issue 8, pp. 1316–1324 [Abstract]
  • Dana Hocková and Antonín Holý
    Synthesis of Some "Abbreviated" NAD+ Analogues
    1997, Vol. 62, Issue 6, pp. 948–956 [Abstract]
  • Zlatko Janeba and Antonín Holý
    Intramolecular cyclization of some (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine derivatives
    1996, Vol. 61, Special Issue, pp. S116–S117 [Abstract]
  • Dana Hocková and Antonín Holý
    "Abbreviated" NAD+ analogues containing a phosphonate function
    1996, Vol. 61, Special Issue, pp. S52–S54 [Abstract]
  • Dana Hocková, Milena Masojídková and Antonín Holý
    "Abbreviated" NAD+ Analogues Containinga Phosphonate Function
    1996, Vol. 61, Issue 10, pp. 1538–1548 [Abstract]
  • Zlatko Janeba, Antonín Holý, Hana Votavová and Milena Masojídková
    Intramolecular Cyclization of Some Acyclic Nucleoside Analogs
    1996, Vol. 61, Issue 3, pp. 442–457 [Abstract]
  • Dana Hocková, Milena Masojídková, Miloš Buděšínský and Antonín Holý
    Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine
    1995, Vol. 60, Issue 2, pp. 224–236 [Abstract]
  • Ivan Votruba, Antonín Holý, Hana Dvořáková, Jaroslav Günter, Dana Hocková, Hubert Hřebabecký, Tomas Cihlar and Milena Masojídková
    Synthesis of 2-Deoxy-β-D-ribonucleosides and 2,3-Dideoxy-β-D-pentofuranosides on Immobilized Bacterial Cells
    1994, Vol. 59, Issue 10, pp. 2303–2330 [Abstract]